When we get a test result for a disease like COVID-19, we naturally expect it to be either positive or negative. But the results of these tests are not so black and white.
Polymerase chain reaction, or “PCR”, is the most common test to detect the presence or absence of SARS-CoV-2, the virus that causes COVID-19.
Recently, a “weak positive” case of COVID-19 was reported in the Northern Territory.
Shouldn’t a test just be ‘positive’ or ‘negative’?
PCR tests are used to detect a range of viruses and pathogens. They look for viral genetic material in a respiratory sample, such as a nose or throat swab or a saliva sample.
We identify a sample to be positive or negative based on the number of times we need to amplify the small segments of genetic material to detect the virus — and whether this number falls below or above a certain threshold.
When might you have a weak positive result?
In most cases, the genetic material of a virus is only detectable when we’re infected and the virus is still replicating and shedding into our respiratory passages.
But sometimes, even when the virus is no longer alive and replicating, it can hang around and be detectable by PCR. In these cases, it’s unclear whether the virus is infectious.
In the case of the NT man, he had earlier tested positive for COVID-19 in Victoria and recovered. Although he recorded a negative test before travelling to the NT, it’s likely he was still just shedding small amounts of the virus.
This may be more common among people with weaker immune systems, as it takes them longer to clear the virus from their system.
The danger of assumption
During a pandemic, there are implications not just for the person being tested, but for their contacts, their workplace, and the whole population.
Incorrectly assuming a weak positive result isn’t COVID-19 could lead to a person continuing to transmit the disease to others. It could also prevent them receiving the proper monitoring and, if necessary, treatment.
Conversely, assuming a weak positive result is COVID-19 when it’s actually negative could lead to the person being unnecessarily quarantined, which has potential personal, psychological and financial effects.